营养不良对静脉麻醉药摄取与分布的影响。一项小鼠研究。
Effect of undernutrition on uptake and distribution of i.v. anaesthetic agents. A study in mice.
作者信息
Saraiva R A, Naganuma L I, Sete M
出版信息
Br J Anaesth. 1978 Apr;50(4):365-9. doi: 10.1093/bja/50.4.365.
The uptake and distribution of two i.v. anaesthetics agents, thiopentone and Althesin, were studied in mice with normal and subnormal nutritional states. The results show that, following the administration of thiopentone, the induction time was signficantly shorter, and that the sleeping time was significantly longer following the administration of Althesin and thiopentone in mice that have low net protein utilization, and decreased total and dry body mass. The increase in the sleeping time in these undernourished mice was 2.2 times greater for Althesin and 4.0 times greater for thiopentone when compared with well-nourished mice.
在营养状态正常和低于正常的小鼠中研究了两种静脉麻醉剂硫喷妥钠和阿法沙龙的摄取和分布情况。结果表明，在给予硫喷妥钠后，诱导时间显著缩短，而在净蛋白质利用率低、总体重和干体重下降的小鼠中，给予阿法沙龙和硫喷妥钠后睡眠时间显著延长。与营养良好的小鼠相比，这些营养不良小鼠的睡眠时间增加幅度，阿法沙龙为2.2倍，硫喷妥钠为4.0倍。
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