硫喷妥钠、氯胺酮、丙泮尼地、α-羟孕酮和地西泮的相对效价。人体统计学研究。
The relative potencies of thiopentone, ketamine, propanidid, alphaxalone and diazepam. A statistical study in man.
作者信息
Stella L, Torri G, Castiglioni C L
出版信息
Br J Anaesth. 1979 Feb;51(2):119-22. doi: 10.1093/bja/51.2.119.
PMID:426987
Abstract
The potency of five i.v. anaesthetics (thiopentone, ketamine, alphaxalone (Althesin), propanidid and diazepam) was studied by determining the dose required to produce unconsciousness in 50% (UD50) and 95% (UD95) of patients. UD50 and UD95 were determined using the probit method. The effect of age on the anaesthetic requirement has been studied also. Relative to thiopentone, the potency was alphaxalone 9.22, diazepam 5.24, ketamine 4.37 and propanidid 1.006.
摘要
通过确定使50%（UD50）和95%（UD95）的患者产生意识丧失所需的剂量，研究了五种静脉麻醉剂（硫喷妥钠、氯胺酮、α-羟孕酮酯钠（阿尔泰辛）、丙泮尼地和地西泮）的效能。使用概率单位法确定UD50和UD95。还研究了年龄对麻醉需求的影响。相对于硫喷妥钠，效能分别为：α-羟孕酮酯钠9.22、地西泮5.24、氯胺酮4.37和丙泮尼地1.006。
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