Jackson A P, Dhadphale P R, Callaghan M L, Alseri S
Br J Anaesth. 1978 Apr;50(4):375-8. doi: 10.1093/bja/50.4.375.
In 14 patients undergoing open-heart operations the haemodynamic effects of diazepam 0.4 mgkg(-1) followed by ketamine 2 mg kg(-1) were studied. In eight patients undergoing coronary bypass surgery, the mean arterial pressure decreased significantly after diazepam from 90.3 +/-7.4 (SEM) to 78.0 +/-5.0 mm Hg (P less than 0.05). However, no changes occurred in six patients undergoing valve replacement. The subsequent administration of ketamine produced no significant changes in mean arterial pressure. No signfiicant change in heart rate occurred in any patient at any time during the period of study. No patient reported unpleasant emergence reactions after operation.
在14例接受心脏直视手术的患者中，研究了先给予0.4mg/kg地西泮然后给予2mg/kg氯胺酮的血流动力学效应。在8例接受冠状动脉搭桥手术的患者中，给予地西泮后平均动脉压显著下降，从90.3±7.4（标准误）降至78.0±5.0mmHg（P<0.05）。然而，在6例接受瓣膜置换手术的患者中未发生变化。随后给予氯胺酮后平均动脉压无显著变化。在研究期间的任何时候，任何患者的心率均未发生显著变化。术后没有患者报告出现不愉快的苏醒反应。
