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1
Macrophage-mediated natural cytotoxicity against various target cells in vitro. II. Macrophages from rats of different ages.巨噬细胞在体外对各种靶细胞的天然细胞毒性。II. 不同年龄大鼠的巨噬细胞。
Br J Cancer. 1978 May;37(5):742-6. doi: 10.1038/bjc.1978.112.
2
Macrophage-mediated natrual cytotoxicity against various target cells in vitro. I. Macrophages from diverse anatomical sites and different strains of rats and mice.巨噬细胞在体外对各种靶细胞的天然细胞毒性。I. 来自不同解剖部位以及不同品系大鼠和小鼠的巨噬细胞。
Br J Cancer. 1978 May;37(5):732-41. doi: 10.1038/bjc.1978.111.
3
Characterization of natural cytotoxicity in vitro in a spontaneous rat tumor model.自发性大鼠肿瘤模型中体外自然细胞毒性的特征分析
J Immunol. 1980 Apr;124(4):1683-90.
4
Solid tumor-derived target cell susceptibility to macrophages and natural killer/natural cytotoxic cells in the rat.大鼠实体瘤来源的靶细胞对巨噬细胞和自然杀伤/自然细胞毒性细胞的敏感性
Immunobiology. 1983 May;164(5):349-60. doi: 10.1016/S0171-2985(83)80031-X.
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Competition between foetal tissue and macrophage-dependent natural tumour resistance.胎儿组织与巨噬细胞依赖性天然肿瘤抗性之间的竞争。
Br J Cancer. 1979 Sep;40(3):417-23. doi: 10.1038/bjc.1979.197.
6
Discrimination between macrophage-and NK-type tumoricidal activities via anti-asialo GM1 antibody.通过抗去唾液酸GM1抗体区分巨噬细胞和NK细胞的杀肿瘤活性。
Exp Cell Biol. 1983;51(3):158-64.
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Strain dependence of rat macrophage natural tumoricidal capacity and its stimulation by endotoxins.大鼠巨噬细胞天然杀肿瘤能力的品系依赖性及其受内毒素的刺激作用
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[Comparative analysis of the sensitivity to natural killers and macrophages of 3-methylcholanthrene-induced tumors in mice].[3-甲基胆蒽诱导的小鼠肿瘤对自然杀伤细胞和巨噬细胞敏感性的比较分析]
Eksp Onkol. 1986;8(6):36-40.
9
Suppression by radioactive strontium of the spontaneous cytotoxicity expressed by adherent, predominantly phagocytic cells from various mouse tissues.放射性锶对来自各种小鼠组织的贴壁、主要为吞噬细胞所表现出的自发细胞毒性的抑制作用。
Immunology. 1979 Jun;37(2):333-8.
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Natural cytotoxicity on tumour cells of human macrophages obtained from diverse anatomical sites.从不同解剖部位获取的人巨噬细胞对肿瘤细胞的天然细胞毒性。
Clin Exp Immunol. 1980 Mar;39(3):776-84.

引用本文的文献

1
Ontogeny of 'macrophage' function. IV. Newborn mouse macrophages strongly suppress tumour cell growth and readily acquire cytolytic activity in comparison with adult macrophages.“巨噬细胞”功能的个体发生。IV. 与成年巨噬细胞相比，新生小鼠巨噬细胞强烈抑制肿瘤细胞生长，并易于获得细胞溶解活性。
Immunology. 1984 Jun;52(2):307-17.
2
Cytotoxicity on tumour cells of human mononuclear phagocytes: defective tumoricidal capacity of alveolar macrophages.人单核吞噬细胞对肿瘤细胞的细胞毒性：肺泡巨噬细胞杀肿瘤能力缺陷
Clin Exp Immunol. 1980 Aug;41(2):336-42.
3
Natural cytotoxicity on tumour cells of human macrophages obtained from diverse anatomical sites.从不同解剖部位获取的人巨噬细胞对肿瘤细胞的天然细胞毒性。
Clin Exp Immunol. 1980 Mar;39(3):776-84.
4
Reduced spontaneous antitumour resistance of the elderly rat is restored by Corynebacterium parvum.短小棒状杆菌可恢复老年大鼠降低的自发性抗肿瘤抵抗力。
Br J Cancer. 1978 Oct;38(4):557-60. doi: 10.1038/bjc.1978.245.
5
Macrophage-mediated natrual cytotoxicity against various target cells in vitro. I. Macrophages from diverse anatomical sites and different strains of rats and mice.巨噬细胞在体外对各种靶细胞的天然细胞毒性。I. 来自不同解剖部位以及不同品系大鼠和小鼠的巨噬细胞。
Br J Cancer. 1978 May;37(5):732-41. doi: 10.1038/bjc.1978.111.
6
Natural cytotoxic macrophages in the peritoneal cavity of mice.小鼠腹腔中的天然细胞毒性巨噬细胞。
Br J Cancer. 1979 Dec;40(6):856-61. doi: 10.1038/bjc.1979.276.
7
Competition between foetal tissue and macrophage-dependent natural tumour resistance.胎儿组织与巨噬细胞依赖性天然肿瘤抗性之间的竞争。
Br J Cancer. 1979 Sep;40(3):417-23. doi: 10.1038/bjc.1979.197.
8
Suppression by radioactive strontium of the spontaneous cytotoxicity expressed by adherent, predominantly phagocytic cells from various mouse tissues.放射性锶对来自各种小鼠组织的贴壁、主要为吞噬细胞所表现出的自发细胞毒性的抑制作用。
Immunology. 1979 Jun;37(2):333-8.

本文引用的文献

1
THE SPECIFICITY OF THE CYTOTOXIC ACTION OF SILICA--A STUDY IN VITRO.二氧化硅细胞毒性作用的特异性——一项体外研究
Br J Exp Pathol. 1963 Aug;44(4):351-64.
2
Cytostatic elimination of syngeneic rat tumor cells in vitro by nonspecifically activated macrophages.非特异性激活的巨噬细胞在体外对同基因大鼠肿瘤细胞的细胞抑制性清除作用。
J Exp Med. 1973 Sep 1;138(3):625-44. doi: 10.1084/jem.138.3.625.
3
An examination of the cytotoxic effects of silica on macrophages.二氧化硅对巨噬细胞细胞毒性作用的研究。
J Exp Med. 1966 Aug 1;124(2):141-54. doi: 10.1084/jem.124.2.141.
4
Macrophage function in the development of immunocompetence and in immunodeficiency.巨噬细胞在免疫能力发育及免疫缺陷中的作用。
J Reticuloendothel Soc. 1976 Jul;20(1):67-70.
5
Effects of Corynebacterium parvum treatment and Toxoplasma gondii infection on macrophage-mediated cytostasis of tumour target cells.短小棒状杆菌治疗及弓形虫感染对巨噬细胞介导的肿瘤靶细胞细胞生长抑制的影响。
Immunology. 1976 Dec;31(6):837-46.
6
Isolation of a subpopulation of adherent peritoneal cells with anti-tumour activity.具有抗肿瘤活性的贴壁腹膜细胞亚群的分离。
Nature. 1976 Mar 11;260(5547):146-8. doi: 10.1038/260146a0.
7
Macrophage-mediated natrual cytotoxicity against various target cells in vitro. I. Macrophages from diverse anatomical sites and different strains of rats and mice.巨噬细胞在体外对各种靶细胞的天然细胞毒性。I. 来自不同解剖部位以及不同品系大鼠和小鼠的巨噬细胞。
Br J Cancer. 1978 May;37(5):732-41. doi: 10.1038/bjc.1978.111.
8
Characterization of the nonphagocytic adherent cell from the peritoneal cavity of normal and BCG-treated mice.正常和卡介苗处理小鼠腹腔中非吞噬性贴壁细胞的特性分析。
J Immunol. 1977 May;118(5):1612-21.
9
Inborn resistance of mice to myxoviruses: macrophages express phenotype in vitro.小鼠对黏液病毒的先天性抗性：巨噬细胞在体外表达表型。
J Exp Med. 1978 Feb 1;147(2):531-40. doi: 10.1084/jem.147.2.531.
10
Promotion of tumor growth in vivo by antimacrophage agents.抗巨噬细胞药物在体内促进肿瘤生长。
J Natl Cancer Inst. 1976 Dec;57(6):1355-61. doi: 10.1093/jnci/57.6.1355.

巨噬细胞在体外对各种靶细胞的天然细胞毒性。II. 不同年龄大鼠的巨噬细胞。

Macrophage-mediated natural cytotoxicity against various target cells in vitro. II. Macrophages from rats of different ages.

作者信息

Keller R

出版信息

Br J Cancer. 1978 May;37(5):742-6. doi: 10.1038/bjc.1978.112.

DOI:10.1038/bjc.1978.112
PMID:656303
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2009632/
Abstract

Adherent, predominantly phagocytic mononuclear cells from various rat tissues express spontaneous cytoxicity against diverse target cells in vitro. The extent to which cytotoxicity was expressed by effector cells depended on the age of donors. Cytolytic effector-cell capacity was already fully developed a few days after birth, and persisted over many months, but was clearly reduced in senescence. Similarly, the ability to intensify natural cytotoxicity by peptone in vivo was already fully manifested in the newborn, but was significantly diminished in old rats.

摘要

来自各种大鼠组织的贴壁、主要为吞噬性的单核细胞在体外对多种靶细胞表现出自发细胞毒性。效应细胞表现出细胞毒性的程度取决于供体的年龄。溶细胞效应细胞能力在出生后几天就已完全发育，并持续数月，但在衰老时明显降低。同样，新生大鼠体内经蛋白胨增强天然细胞毒性的能力已完全显现，但老年大鼠的这种能力则显著减弱。