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[使用等电聚焦法证明一种“新的”BF变体(BF S柏林型)]

[Demonstration of a "new" BF-variant (BF S Berlin) using isoelectric focusing].

作者信息

Geserick G, Patzelt D, Schröder H

出版信息

Biomed Biochim Acta. 1984;43(2):255-7.

PMID:6563915
Abstract

Using the islelectrofucising in polyacrylamide gel for BF typing in the population from Berlin (GDR) a "new" variant was found. This variant is situated cathodically of the BF S line, but it is not detectable by means of agarose gel electrophoresis. Therefore the common BF nomenclature is not applicable. The designation "S Berlin" is proposed. Typing the family of the proposita the same phenotype (S Svar .) was found in the serum of her daughter. This result confirms a codominant inheritance of the new allele. The observed allele frequency is 0.0017.

摘要

在民主德国柏林人群中,利用聚丙烯酰胺凝胶等电聚焦法进行BF分型时发现了一种“新”变体。该变体位于BF S线的阴极侧,但用琼脂糖凝胶电泳无法检测到。因此,常用的BF命名法不适用。建议命名为“S柏林”。对先证者的家族进行分型时,在其女儿的血清中发现了相同的表型(S变种)。这一结果证实了新等位基因的共显性遗传。观察到的等位基因频率为0.0017。

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