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帕金森病中的哪种运动障碍表明了基底神经节的真正运动功能?

Which motor disorder in Parkinson's disease indicates the true motor function of the basal ganglia?

作者信息

Marsden C D

出版信息

Ciba Found Symp. 1984;107:225-41. doi: 10.1002/9780470720882.ch12.

Abstract

Parkinson's disease in its earlier stages is argued to be the best available model for human basal ganglia dysfunction. The negative motor symptoms of Parkinson's disease are considered to give the greatest clue to normal function of this region of the brain. Particular attention is given to disorders of movement. These include delayed initiation and slowed execution of simple fast movements, due to abnormal specification of initial agonist activity. This might compromise predictive motor action, but this is shown to be preserved in Parkinson's disease. Disorders of more complex movements, such as repetitive, concurrent and sequential motor actions, are also abnormal in Parkinson's disease. These various defects are discussed in terms of a motor strategy involving the selection and sequencing of motor programmes to form a motor plan, and the initiation and execution of that motor plan. On the evidence available, it is suggested that patients with Parkinson's disease are unable to automatically execute learnt motor plans.

摘要

帕金森病的早期阶段被认为是人类基底神经节功能障碍的最佳可用模型。帕金森病的负性运动症状被认为是该脑区正常功能的最大线索。人们特别关注运动障碍。这些障碍包括简单快速运动的起始延迟和执行缓慢,这是由于初始激动剂活动的异常设定所致。这可能会损害预测性运动动作,但研究表明在帕金森病中这种能力得以保留。更复杂的运动障碍,如重复性、同时性和连续性运动动作,在帕金森病中也不正常。根据一种运动策略来讨论这些不同的缺陷,该策略涉及运动程序的选择和排序以形成运动计划,以及该运动计划的启动和执行。根据现有证据,提示帕金森病患者无法自动执行已习得的运动计划。

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