Marsden C D
Can J Neurol Sci. 1984 Feb;11(1 Suppl):129-35. doi: 10.1017/s031716710004628x.
Early Parkinson's disease is taken to be the best human model of disordered basal ganglia function. An experimental study in Parkinsonians with swings in motor response to drug treatment suggests that general cognition is not controlled by dopamine mediated striatal activity. The variety of motor disorders in Parkinson's disease cannot be explained by simple concepts. Although Parkinsonians cannot execute fast ballistic movements, an experimental study shows that they can adopt a predictive motor control strategy. It is argued that simple motor programs are not grossly disturbed in Parkinson's disease. It is concluded that Parkinsonians cannot automatically execute learned motor plans.
早期帕金森病被视为基底神经节功能紊乱的最佳人类模型。一项针对帕金森病患者的实验研究，观察了他们对药物治疗的运动反应波动情况，结果表明，一般认知并非由多巴胺介导的纹状体活动所控制。帕金森病中运动障碍的多样性无法用简单的概念来解释。尽管帕金森病患者无法执行快速的弹道式运动，但一项实验研究表明，他们能够采用预测性运动控制策略。有人认为，简单的运动程序在帕金森病中并未受到严重干扰。研究得出的结论是，帕金森病患者无法自动执行已学的运动计划。
