Pérez-López F R, Urcia M, Torralba R, Lafarga L, Hergueta J
Cancer Lett. 1984 Aug;24(1):111-8. doi: 10.1016/0304-3835(84)90087-9.
The chemotherapeutic effectiveness of intraperitoneal administration of prospidine (50 mg/kg per day during the initial 14 days of study) was evaluated, on a circadian basis, on the N-nitrosomethylurea (NMU)-induced mammary tumors in female rats. Untreated rats showed a progressive increase in the mean tumor area and total tumor area/rat. At the end of treatment the average tumor area and total tumor area/rat in the animals treated at 0800, 1400 and 2000 h were significantly lower than the values in the control group by week 2. By weeks 3 and 4 the mean tumor area and total tumor area in all groups of treated rats were significantly lower than those in the untreated animals. The mean tumor area by weeks 5 and 6 in the animals treated at 0800 h were significantly lower than in the group treated at 0200 h, and the mean value by week 6 in the group treated at 1400 h was significantly lower than those from the groups treated either at 2000 h or 0200 h. The mean total tumor area/rat in rats treated at 1400 h was, by week 6, significantly lower than in animals treated either at 2000 h or 0200 h. A transient reduction in body weight was registered at the end of prospidine treatment.
在雌性大鼠中，以昼夜节律为基础，评估了腹腔注射丙胺亚胺（在研究的最初14天，每天50毫克/千克）对N-亚硝基甲基脲（NMU）诱导的乳腺肿瘤的化疗效果。未治疗的大鼠平均肿瘤面积和每只大鼠的总肿瘤面积呈逐渐增加趋势。在治疗结束时，在08:00、14:00和20:00接受治疗的动物，其平均肿瘤面积和每只大鼠的总肿瘤面积在第2周时显著低于对照组的值。到第3周和第4周时，所有治疗组大鼠的平均肿瘤面积和总肿瘤面积均显著低于未治疗动物。在第5周和第6周时，08:00接受治疗的动物的平均肿瘤面积显著低于02:00接受治疗的组，在第6周时，14:00接受治疗的组的平均值显著低于20:00或02:00接受治疗的组。到第6周时，14:00接受治疗的大鼠每只大鼠的平均总肿瘤面积显著低于20:00或02:00接受治疗的动物。在丙胺亚胺治疗结束时，记录到体重有短暂下降。
