Mackillop W J, Ciampi A, Till J E, Buick R N
J Natl Cancer Inst. 1983 Jan;70(1):9-16.
A simple stem cell model of human tumor growth is presented. Three tumor cell populations are predicted: stem, transitional, and end cells. The properties of these cells are discussed in terms of their behavior in currently available technologies for investigation of cell kinetics and for their influence on clinical outcome. Stem cell renewal, transitional cell proliferation, and cell loss are analyzed mathematically to define their influence on the relative proportions of cell populations; it is demonstrated that stem cell renewal has a central role in determining the growth properties of tumors. The impact of a stem cell model on the use of tumor clonogenic assays as predictors of clinical outcome is discussed; opinions are expressed as to the definition of reasonable expectations for current experimental procedures.
提出了一种人类肿瘤生长的简单干细胞模型。预测了三种肿瘤细胞群体：干细胞、过渡细胞和终末细胞。根据这些细胞在当前用于研究细胞动力学的技术中的行为及其对临床结果的影响，讨论了它们的特性。对干细胞更新、过渡细胞增殖和细胞丢失进行了数学分析，以确定它们对细胞群体相对比例的影响；结果表明，干细胞更新在决定肿瘤生长特性方面起着核心作用。讨论了干细胞模型对将肿瘤克隆形成试验用作临床结果预测指标的影响；对当前实验程序的合理预期定义表达了观点。
