Schüpbach P M
Oral Surg Oral Med Oral Pathol. 1983 Jan;55(1):2-9. doi: 10.1016/0030-4220(83)90296-7.
Incomplete clefts of the hard palate with soft-palate integrity are among the rarest malformations found in human beings. They appear as oval-shaped openings in the midline of the hard palate and do not extend along its whole length. The amniotic-sac-puncture technique was used to induce such clefts in 10 percent of a group of rat fetuses at day 15.3 of pregnancy. The upper jaws of such fetuses, either 17.3 or 21.3 days old, were examined in the scanning electron microscope and in serial Epon sections. At day 17.3 incomplete clefts of the hard palate were extending toward the soft palate, with the anterior portion of palatal shelves still in the vertical position and with the soft palate already fused. At day 21.3, the incomplete hard-palate clefts were smaller in both extension and width. These observations support the idea that fusion of the soft palate can occur independently of fusion in the hard-palate region.
硬腭裂合并软腭完整是人类中极为罕见的畸形之一。它们表现为硬腭中线处椭圆形的开口，且不沿硬腭全长延伸。在妊娠第15.3天，采用羊膜囊穿刺技术在一组大鼠胎儿的10%中诱导出此类腭裂。对这些17.3天或21.3天大的胎儿的上颌骨进行了扫描电子显微镜检查和连续环氧树脂切片检查。在第17.3天，硬腭的不完全腭裂正朝着软腭延伸，腭突的前部仍处于垂直位置，而软腭已经融合。在第21.3天，不完全硬腭裂在延伸和宽度上都变小了。这些观察结果支持了软腭融合可以独立于硬腭区域融合而发生的观点。
