Department of Orthodontics and Craniofacial Biology, at the Nijmegen Centre for Molecular Life Sciences of the Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Tissue Eng Part B Rev. 2012 Dec;18(6):468-77. doi: 10.1089/ten.TEB.2012.0049. Epub 2012 Jul 19.
Children with a cleft in the soft palate have difficulties with speech, swallowing, and sucking. These patients are unable to separate the nasal from the oral cavity leading to air loss during speech. Although surgical repair ameliorates soft palate function by joining the clefted muscles of the soft palate, optimal function is often not achieved. The regeneration of muscles in the soft palate after surgery is hampered because of (1) their low intrinsic regenerative capacity, (2) the muscle properties related to clefting, and (3) the development of fibrosis. Adjuvant strategies based on tissue engineering may improve the outcome after surgery by approaching these specific issues. Therefore, this review will discuss myogenesis in the noncleft and cleft palate, the characteristics of soft palate muscles, and the process of muscle regeneration. Finally, novel therapeutic strategies based on tissue engineering to improve soft palate function after surgical repair are presented.
腭裂儿童在言语、吞咽和吮吸方面存在困难。这些患者无法将鼻腔与口腔分开，导致言语时空气流失。虽然手术修复通过连接软腭的裂肌来改善软腭功能，但通常无法达到最佳效果。由于（1）肌肉内在再生能力低，（2）与腭裂相关的肌肉特性，以及（3）纤维化的发展，手术后软腭肌肉的再生受到阻碍。基于组织工程的辅助策略可以通过解决这些具体问题来改善手术后的效果。因此，本综述将讨论非腭裂和腭裂中的成肌发生、软腭肌肉的特征以及肌肉再生过程。最后，提出了基于组织工程的新的治疗策略，以改善手术修复后的软腭功能。
