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Three chromosomes' (7;9;22) rearrangement and the origin of the Philadelphia chromosome.

作者信息

Francesconi D, Pasquali F

出版信息

Hum Genet. 1978 Aug 31;43(2):133-7. doi: 10.1007/BF00293590.

DOI:10.1007/BF00293590
PMID:278772
Abstract

A woman with chronic myelocytic leukemia had the Philadelphia chromosome and a complex four-break--three-chromosome rearrangement. The q32 leads to q34 portion of chromosome 9 is translocated to band q22 of chromosome 7, and at the end of this segment is attached the deleted q11 leads to qter portion of chromosome 22. A review of 12 cases of the Philadelphia chromosome originating by the rearrangement of three or more chromosomes reveals that chromosomes 9 and 22 are always involved, while the third chromosome is a different one in each case. We discuss the hypothesis that the 22q segment is always specifically attached to band 9q34 wherever this portion of 9q is transposed.

摘要

相似文献

1
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2
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引用本文的文献

1
New complex Ph' translocation t (10; 14; 22) in bone marrow cells and in PHA-stimulated peripheral blood cultures in chronic myelocytic leukaemia.慢性粒细胞白血病骨髓细胞及PHA刺激的外周血培养物中出现新的复杂Ph'易位t(10;14;22) 。
J Cancer Res Clin Oncol. 1980;96(3):287-94. doi: 10.1007/BF00408101.
2
Transposition of 9q34 and 22 (q11toqter) regions has a specific role in chronic myelocytic leukemia.
Hum Genet. 1979 Nov 1;52(1):55-67. doi: 10.1007/BF00284598.
3
Translocation between chromosome 7 and chromosome 22, t(7;22)(p22;q12), in a patient with chronic myelocytic leukemia.
Hum Genet. 1979 Jun 19;49(2):225-7. doi: 10.1007/BF00277647.

本文引用的文献

1
Two complex translocations in chronic granulocytic leukemia involving chromosomes 22, 9, and a third chromosome.慢性粒细胞白血病中涉及22号、9号染色体及第三条染色体的两个复杂易位。
Humangenetik. 1975 Oct 20;30(1):13-21. doi: 10.1007/BF00273627.
2
Structural rearrangements associated with the Ph1 chromosome in chronic granulocytic leukaemia.
Humangenetik. 1975 Sep 23;29(3):223-8. doi: 10.1007/BF00297627.
3
Chromosomes and causation of human cancer and leukemia. XVI. Banding studies of chronic myelocytic leukemia, including five unusual Ph11 translocations.染色体与人类癌症和白血病的病因。十六。慢性粒细胞白血病的染色体带型研究，包括五例异常的Ph11易位
Cancer. 1975 Oct;36(4):1177-91. doi: 10.1002/1097-0142(197510)36:4<1177::aid-cncr2820360402>3.0.co;2-8.
4
A case of chronic myeloid leukemia with a translocation (12;22)(p13;q11).
Hum Genet. 1977 Nov 10;39(2):229-31. doi: 10.1007/BF00287017.
5
A new translocation involving three chromosomes in chronic myelocytic leukemia, 46,XY,t(9;11;22).
Cytogenet Cell Genet. 1977;18(2):75-81. doi: 10.1159/000130750.
6
Chronic myelocytic leukemia with a masked Ph1 chromosome.
N Engl J Med. 1977 Mar 10;296(10):571-2. doi: 10.1056/NEJM197703102961015.