Klain M, Keszler H, Stool S
Crit Care Med. 1983 Mar;11(3):170-2. doi: 10.1097/00003246-198303000-00004.
Aspiration is a potentially fatal complication of artificial ventilation. A cuffed tube is generally used now to prevent aspiration; however, it may lead to serious complications and has several disadvantages. High frequency jet ventilation (HFJV) is an innovative technique to prevent aspiration. The trachea of 6 anesthetized, paralyzed dogs was exposed and a catheter for jet ventilation introduced between the 1st and 2nd tracheal ring. Another catheter was used for measuring intratracheal pressure. An endoscope was inserted into the trachea about 2 inches lower down and directed upwards to give a view of the vocal cords from below. A mixture of saliva, saline, and cardiogreen was introduced into the mouth so as to form a pool. When observation confirmed that HFJV prevents aspiration at frequencies of 100/min and ratios of inspiration/expiration (I:E) equalling 1:1, observations were repeated at I:E, 1:2 and 1:3 and at rates of 60/min and 200/min. The depth of the pool was gradually increased to between 2 and 31/4 inches and observations were repeated. Endoscopy alone was used in 4 animals and endoscopic film in 2 to evaluate the efficacy of HFJV. The results showed convincingly that: (1) HFJV can prevent fluid from entering the larynx from above; (2) this effect is unreliable when the frequency is decreased to 60/min or inspiration becomes shorter than 33% of the cycle; (3) intratracheal end-expiratory pressures show values slightly higher than the fluid level above the cords; and (4) the cords are separated and the gas mixture bubbles through the fluid. We conclude that (a) valve mechanisms cannot account for our observations; and (b) at rates above 60/min and with duration of expiration of 66% or less, HFJV will prevent aspiration by causing a continuous gas flow outward through the larynx. This is associated with a low continuous positive airway pressure and excellent blood gases.
误吸是人工通气的一种潜在致命并发症。现在一般使用带套囊的气管导管来防止误吸;然而,它可能会导致严重并发症且有几个缺点。高频喷射通气(HFJV)是一种防止误吸的创新技术。暴露6只麻醉、麻痹犬的气管,在第1和第2气管环之间插入用于喷射通气的导管。另一个导管用于测量气管内压力。将内镜插入气管下方约2英寸处并向上指向,以便从下方观察声带。将唾液、生理盐水和心绿素的混合物引入口腔以形成一个液池。当观察证实HFJV在频率为100次/分钟且吸气/呼气比(I:E)等于1:1时可防止误吸时,在I:E为1:2和1:3以及频率为60次/分钟和200次/分钟时重复观察。逐渐将液池深度增加到2至3又1/4英寸之间并重复观察。4只动物仅使用内镜检查,2只动物使用内镜胶片来评估HFJV的效果。结果令人信服地表明:(1)HFJV可防止液体从上方进入喉部;(2)当频率降至60次/分钟或吸气时间短于周期的33%时,这种效果不可靠;(3)气管内呼气末压力显示的值略高于声带上方的液位;(4)声带分开,气体混合物气泡穿过液体。我们得出结论:(a)瓣膜机制无法解释我们的观察结果;(b)在频率高于60次/分钟且呼气持续时间为66%或更短时,HFJV将通过使持续气流向外通过喉部来防止误吸。这与低持续气道正压和良好的血气相关。