Patel K, Bakhle Y S
Prostaglandins Leukot Med. 1983 Mar;10(3):221-9. doi: 10.1016/0262-1746(82)90079-8.
In rat isolated lung perfused via the pulmonary circulation, 3H-TxB2 was metabolized to another radioactive species. About 60% of effluent 3H was metabolite and the same proportion of metabolite was found in lung at 5 min after the injection of 3H-TxB2. Metabolism of TxB2 was prevented by bromcresol green, dipyridamole and frusemide apparently by decreasing uptake of TxB2 by the lung. Our results support the possibility of TxB2 competing with PGE2 for metabolism in lung, although TxB2 is not a substrate for PGDH in vitro.
在通过肺循环灌注的大鼠离体肺中，3H-TxB2代谢为另一种放射性物质。约60%的流出物3H为代谢产物，在注射3H-TxB2后5分钟，肺中也发现了相同比例的代谢产物。溴甲酚绿、双嘧达莫和呋塞米可通过明显减少肺对TxB2的摄取来阻止TxB2的代谢。我们的结果支持TxB2在肺中与PGE2竞争代谢的可能性，尽管TxB2在体外不是PGDH的底物。
