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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Boura A L, Murphy R D

Clin Exp Pharmacol Physiol. 1978 Jul-Aug;5(4):387-92. doi: 10.1111/j.1440-1681.1978.tb00688.x.

The effect of thromboxane B2 (TxB2) on inactivation of prostaglandin E2 (PGE2) by the rat isolated perfused lung has been studied. 2. TxB2 when infused in low concentrations (100 ng/ml) into the pulmonary artery reduced PGE2 inactivation approximately two-fold. 3. The rat isolated fundus strip was contracted by higher concentrations of TxB2 (1.0 microgram/ml) in the presence of hyoscine, mepyramine, methysergide, phenoxybenzamine and propranolol. The size of contraction was reduced by indomethacin in concentrations known to inhibit prostaglandin synthetase. 4. Thus, in circumstances in which TxB2 and PGE2 are released concomitantly by the lung, low concentrations of TxB2 may augment PGE2 release by reducing its inactivation.

研究了血栓素B2（TxB2）对大鼠离体灌注肺灭活前列腺素E2（PGE2）的影响。2. 当以低浓度（100 ng/ml）注入肺动脉时，TxB2使PGE2灭活减少约两倍。3. 在存在东莨菪碱、甲氧苄胺嘧啶、甲基麦角新碱、酚苄明和普萘洛尔的情况下，较高浓度（1.0微克/毫升）的TxB2使大鼠离体胃底条收缩。已知抑制前列腺素合成酶的吲哚美辛浓度可使收缩幅度减小。4. 因此，在肺同时释放TxB2和PGE2的情况下，低浓度的TxB2可能通过减少其灭活来增加PGE2的释放。

Boura A L, Murphy R D

Clin Exp Pharmacol Physiol. 1978 Jul-Aug;5(4):387-92. doi: 10.1111/j.1440-1681.1978.tb00688.x.

The effect of thromboxane B2 (TxB2) on inactivation of prostaglandin E2 (PGE2) by the rat isolated perfused lung has been studied. 2. TxB2 when infused in low concentrations (100 ng/ml) into the pulmonary artery reduced PGE2 inactivation approximately two-fold. 3. The rat isolated fundus strip was contracted by higher concentrations of TxB2 (1.0 microgram/ml) in the presence of hyoscine, mepyramine, methysergide, phenoxybenzamine and propranolol. The size of contraction was reduced by indomethacin in concentrations known to inhibit prostaglandin synthetase. 4. Thus, in circumstances in which TxB2 and PGE2 are released concomitantly by the lung, low concentrations of TxB2 may augment PGE2 release by reducing its inactivation.

研究了血栓素B2（TxB2）对大鼠离体灌注肺灭活前列腺素E2（PGE2）的影响。2. 当以低浓度（100 ng/ml）注入肺动脉时，TxB2使PGE2灭活减少约两倍。3. 在存在东莨菪碱、甲氧苄胺嘧啶、甲基麦角新碱、酚苄明和普萘洛尔的情况下，较高浓度（1.0微克/毫升）的TxB2使大鼠离体胃底条收缩。已知抑制前列腺素合成酶的吲哚美辛浓度可使收缩幅度减小。4. 因此，在肺同时释放TxB2和PGE2的情况下，低浓度的TxB2可能通过减少其灭活来增加PGE2的释放。