Bernstein I L, Goehler L E
Behav Neurosci. 1983 Apr;97(2):290-8. doi: 10.1037//0735-7044.97.2.290.
A modified learned food aversion paradigm simulated the prolonged food and illness exposure likely to characterize nutrient deficiencies or tumor growth. In this paradigm, a continuously available food was associated with a slow, continuous infusion of LiCl provided by osmotic minipump. Significant aversions were acquired when the available diet was novel but not when it was familiar. Effects of drug infusions on daily food intake were found to parallel those on aversion formation. Marked, persistent suppression of food intake was seen in drug-treated animals consuming a novel diet, but only transient declines were seen in those with a familiar diet. By separating the direct from the conditioned effects on food intake of chronic drug infusions, these studies provided strong evidence that learned food aversions can lead to anorexia.
一种改良的习得性食物厌恶范式模拟了长时间的食物与疾病接触，这种接触可能是营养缺乏或肿瘤生长的特征。在该范式中，一种持续可得的食物与通过渗透微型泵缓慢、持续输注的氯化锂相关联。当可得饮食是新的时会产生显著的厌恶，但当饮食是熟悉的时则不会。发现药物输注对每日食物摄入量的影响与对厌恶形成的影响相似。在食用新饮食的药物治疗动物中观察到食物摄入量明显、持续的抑制，但在食用熟悉饮食的动物中仅观察到短暂下降。通过区分慢性药物输注对食物摄入的直接影响和条件性影响，这些研究提供了有力证据表明习得性食物厌恶可导致厌食。
