Bernstein I L, Fenner D P
Appetite. 1983 Jun;4(2):79-86. doi: 10.1016/s0195-6663(83)80004-x.
Learned food aversions have been implicated in the anorexia which develops in rats with transplantable PW-739 tumors. There appear to be striking differences in growth characteristics and physiological effects of different experimental tumors. The present studies examined the issue of heterogeneity of tumor models, while assessing the generality of the finding that learned food aversions arise in anorexic, tumor-bearing animals. This was done by comparing effects on food intake and diet preferences of two transplantable tumors, the Leydig cell tumor, LTW(m), and the Walker-256 carcinosarcoma. We found that animals with Leydig tumors, like those with PW-739 tumors, developed strong aversions to the specific diet they had eaten after tumor implant. In contrast, animals with Walker-256 tumors did not develop diet aversions. These results support the idea that learned food aversions contribute to anorexia in animals with Leydig but not Walker tumors. They further suggest that learned food aversions in tumor-bearing animals are not a response to illness, in general, but rather that the unconditioned stimulus responsible for these aversions is quite specific, and may ultimately prove identifiable.
习得性食物厌恶与移植了PW - 739肿瘤的大鼠所发生的厌食症有关。不同实验性肿瘤的生长特性和生理效应似乎存在显著差异。本研究探讨了肿瘤模型的异质性问题，同时评估了厌食的荷瘤动物会出现习得性食物厌恶这一发现的普遍性。这是通过比较两种可移植肿瘤，即睾丸间质细胞瘤LTW(m)和Walker - 256癌肉瘤对食物摄入量和饮食偏好的影响来实现的。我们发现，患有睾丸间质细胞瘤的动物，与患有PW - 739肿瘤的动物一样，在肿瘤植入后对它们所食用的特定饮食产生了强烈的厌恶。相比之下，患有Walker - 256肿瘤的动物没有出现饮食厌恶。这些结果支持了这样一种观点，即习得性食物厌恶导致了患有睾丸间质细胞瘤而非Walker肿瘤的动物出现厌食症。它们进一步表明，荷瘤动物的习得性食物厌恶总体上不是对疾病的反应，而是导致这些厌恶的无条件刺激相当特定，最终可能被证明是可识别的。
