Clavier R M, Chambers J W, Coscina D V
Brain Res Bull. 1983 Mar;10(3):321-5. doi: 10.1016/0361-9230(83)90098-9.
Histochemical fluorescence microscopy has been used to study changes over a 15-week period in the density of catecholaminergic (CA) varicosities in medial hypothalamic nuclei of rats made hyperphagic by bilateral perifornical parasagittal knife cuts. The average daily intake of food was highest when measured two days after the knife cuts. By the 7th post-cut day, daily food intake was comparable to that measured during the 10th and 11th weeks after the cuts. The number of fluorescent varicosities in the paraventricular and periventricular hypothalamic nuclei diminished steadily after the knife cuts until they were virtually absent by the end of the fourth week. This process then reversed itself so that by the end of the 15th week the varicosities in these nuclei numbered just over 50% of presurgical values. Thus, there was an apparent lack of correspondence between increases in ingestive behavior or body weight and the nature of the CA innervation of the medial hypothalamus. This finding supports previously published work which indicates that the noradrenergic control of feeding behavior in the medial hypothalamus is mediated by a neural system that acts independently of the system responsible for the knife cut-induced hyperphagic response.
组织化学荧光显微镜已被用于研究双侧穹窿周矢状刀切割致食欲亢进大鼠下丘脑内侧核中儿茶酚胺能（CA）曲张体密度在15周内的变化。在刀切割后两天测量时，食物的平均日摄入量最高。到切割后第7天，每日食物摄入量与切割后第10周和第11周测量的摄入量相当。下丘脑室旁核和室周核中荧光曲张体的数量在刀切割后稳步减少，直到第四周结束时几乎消失。然后这个过程发生逆转，以至于到第15周结束时，这些核中的曲张体数量仅略高于手术前值的50%。因此，摄食行为或体重的增加与下丘脑内侧CA神经支配的性质之间明显缺乏对应关系。这一发现支持了先前发表的研究工作，该研究表明下丘脑内侧进食行为的去甲肾上腺素能控制是由一个独立于负责刀切割诱导的食欲亢进反应的系统起作用的神经系统介导的。
