Nishino H, Nagamatsu M, Ishii S, Takamatsu S, Saito J, Yamanaka K
Jpn J Antibiot. 1983 Feb;36(2):398-407.
The concentrations of cefotetan (CTT) in serum, uterus, ovary and oviduct tissues were determined in 30 patients after single intravenous drip infusion of 1 g over 1 hour. 1. Peripheral blood level of CTT was determined from 3 to 24 hours after injection. The maximum level was observed at 3 hours after injection and the concentration went down gradually with time. 2. The tissue concentrations of CTT in intrapelvic organs also tended to decrease with time and hardly detected 24 hours after injection. 3. From 3 to 12 hours after injection, mean penetration rate of CTT into intrapelvic organs was 40% and more. 4. Among intrapelvic organs, penetration rate into portio was highest, and others were ovary, uterine cervix, oviduct, endometrium, myometrium and uterine myoma in order of lowering penetration rate. 5. The penetration rate into uterine myoma was approximately half that into normal tissue. Considering above results, CTT is expected to show sufficient effects against Gram-negative bacilli and Bacteroides sp. when reasonably dosed.
对30例患者在1小时内单次静脉滴注1g头孢替坦（CTT）后，测定血清、子宫、卵巢和输卵管组织中CTT的浓度。1. 注射后3至24小时测定外周血CTT水平。注射后3小时观察到最高水平，且浓度随时间逐渐下降。2. 盆腔内器官中CTT的组织浓度也随时间趋于下降，注射后24小时几乎检测不到。3. 注射后3至12小时，CTT进入盆腔内器官的平均渗透率为40%及以上。4. 在盆腔内器官中，进入宫颈的渗透率最高，其他依次为卵巢、子宫颈、输卵管、子宫内膜、子宫肌层和子宫肌瘤，渗透率依次降低。5. 进入子宫肌瘤的渗透率约为进入正常组织的一半。考虑到上述结果，合理给药时，CTT有望对革兰氏阴性杆菌和拟杆菌属显示出足够的疗效。
