Kellner C H, Rubinow D R, Gold P W, Post R M
Psychiatry Res. 1983 Mar;8(3):191-7. doi: 10.1016/0165-1781(83)90062-8.
Preliminary data showing a correlation between urinary free cortisol levels and ventricular-brain ratio in 10 affectively ill patients are presented. The literature on hypercortisolism and computed tomography (CT scan) abnormalities is reviewed. The authors suggest that the increased cortisol production in some psychiatric patients might be capable of altering the gross structure of the brain and that such alterations might be reversible.
