Verkasalo M, Kuitunen P, Tiilikainen A, Savilahti E
Acta Paediatr Scand. 1983 Jan;72(1):19-22. doi: 10.1111/j.1651-2227.1983.tb09657.x.
The histocompatibility antigens of one hundred patients with a severe form of cow's milk allergy were studied. HLA-A and B locus antigens were identified in all patients, C locus antigens in 62 patients and DR locus antigens in 41 patients. The A, B and C locus antigen frequencies were compared with those of healthy blood donors, and DR locus antigen frequencies with those of healthy unrelated volunteers and cadaver kidney donors. The series included six patients with concomitant coeliac disease, who were treated as a separate group. No statistically significant differences between the patients and controls were observed, but suggestive differences became apparent when the patient group was divided into subgroups according to the presence or absence of certain co-existing conditions, and the severity of the initially observed intestinal lesion. It is concluded that several factors contribute to the pathogenesis of intestinal cow's milk allergy, and that in some cases genes linked to the HLA region may play a role.
对100例重度牛奶过敏患者的组织相容性抗原进行了研究。所有患者均鉴定出HLA - A和B位点抗原，62例患者鉴定出C位点抗原，41例患者鉴定出DR位点抗原。将A、B和C位点抗原频率与健康献血者的频率进行比较，将DR位点抗原频率与健康无关志愿者和尸体肾供者的频率进行比较。该系列包括6例伴有乳糜泻的患者，将他们作为一个单独的组进行治疗。患者与对照组之间未观察到统计学上的显著差异，但当根据某些共存疾病的存在与否以及最初观察到的肠道病变的严重程度将患者组分为亚组时，出现了一些提示性差异。得出的结论是，有几个因素促成了肠道牛奶过敏的发病机制，并且在某些情况下，与HLA区域相关的基因可能起作用。
