Swinson C M, Hall P J, Bedford P A, Booth C C
Gut. 1983 Oct;24(10):925-8. doi: 10.1136/gut.24.10.925.
Coeliac patients are at greater risk than the general population of developing malignant neoplasms, particularly lymphomas. The establishment at the Clinical Research Centre of a national collaborative study of coeliac patients with malignancy provided the opportunity to carry out HLA typing for 55 HLA-A, B and C and the 10 recognised DR antigens on a group of coeliac patients with malignancy. Study of a sample of 44 patients with biopsy proven coeliac disease and histologically confirmed malignancy, including 12 with malignant histiocytosis, and 57 coeliac patients without malignancy, failed to show any significant differences in antigen frequencies between patients with and without malignancy. These results indicate that there are no HLA genetic markers associated specifically with the development of malignancy in coeliac disease.
乳糜泻患者患恶性肿瘤，尤其是淋巴瘤的风险高于普通人群。临床研究中心开展的一项针对患有恶性肿瘤的乳糜泻患者的全国性合作研究，为一组患有恶性肿瘤的乳糜泻患者进行55种HLA - A、B和C以及10种公认的DR抗原的HLA分型提供了机会。对44例经活检证实患有乳糜泻且组织学确诊为恶性肿瘤的患者样本进行研究，其中包括12例恶性组织细胞增多症患者，以及57例无恶性肿瘤的乳糜泻患者，结果显示恶性肿瘤患者与无恶性肿瘤患者之间的抗原频率无显著差异。这些结果表明，在乳糜泻中不存在与恶性肿瘤发生特异性相关的HLA遗传标记。
