Chu J Y, Demello D, O'Connor D M, Chen S C, Gale G B
Cancer. 1983 Jul 15;52(2):322-4. doi: 10.1002/1097-0142(19830715)52:2<322::aid-cncr2820520222>3.0.co;2-u.
A case of acute nonlymphocytic leukemia presenting as pericarditis is reported in a five-year-old boy. Initially, a clinical diagnosis of viral pericarditis was made, because the child did not demonstrate hematologic or clinical manifestations of leukemia. Acute undifferentiated or lymphocytic leukemia. Acute undifferentiated or lymphocytic leukemia was diagnosed one week after admission when his peripheral blood count became abnormal. The patient did not respond to vincristine and prednisone. When cytochemical evaluation indicated acute myelomonocytic leukemia, employment of cytosine arabinoside and 6-thioguanine was instituted and the child began to improve. Currently, he is still in good remission and has no evidence of recurrence of pericarditis, 1 1/2 years after his initial presentation. In reviewing the literature, we found 17 patients who had leukemic pericardial effusion with cardiac tamponade. There are three reported cases of young children with pericardial effusion as the initial manifestation of acute lymphocytic leukemia, but no reported cases due to nonlymphocytic leukemia, as in this child.
本文报告了一名5岁男孩，以心包炎为表现的急性非淋巴细胞白血病病例。最初，由于该患儿未表现出血液学或白血病的临床表现，临床诊断为病毒性心包炎。入院一周后，外周血细胞计数出现异常，诊断为急性未分化或淋巴细胞白血病。该患者对长春新碱和泼尼松无反应。当细胞化学评估显示为急性粒单核细胞白血病时，开始使用阿糖胞苷和6-硫鸟嘌呤治疗，患儿病情开始好转。目前，自首次出现症状1年半后，他仍处于良好的缓解状态，且无心包炎复发的迹象。在查阅文献时，我们发现有17例白血病性心包积液伴心脏压塞的患者。有3例报道称幼儿以心包积液为急性淋巴细胞白血病的首发表现，但尚无如该患儿因非淋巴细胞白血病导致心包积液的报道。
