Ehrsson H, Hassan M, Ehrnebo M, Beran M
Clin Pharmacol Ther. 1983 Jul;34(1):86-9. doi: 10.1038/clpt.1983.134.
Busulfan kinetics were studied in patients with chronic myelocytic leukemia after oral doses of 2, 4, and 6 mg. The plasma concentration-time data could be fitted to a zero-order absorption one-compartment open model. The elimination rate constant averaged 0.27 +/- 0.05 hr-1 (SD). The plasma AUC was linearly related to the dose. The lag time for the start of absorption, the time absorption ends, and the absorption rate constant showed some interindividual variations. About 1% of busulfan is excreted unchanged in urine over 24 hr.
对慢性粒细胞白血病患者口服2毫克、4毫克和6毫克剂量的白消安后的动力学进行了研究。血浆浓度-时间数据可拟合为零级吸收单室开放模型。消除速率常数平均为0.27±0.05小时-1（标准差）。血浆药时曲线下面积（AUC）与剂量呈线性相关。吸收开始的滞后时间、吸收结束时间和吸收速率常数存在个体间差异。24小时内约1%的白消安以原形经尿液排泄。
