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一种以全身性糖原贮积症为特征的日本鹌鹑(Coturnix coturnix japonica)新突变体。

A new mutant of Japanese quail (Coturnix coturnix japonica) characterized by generalized glycogenosis.

作者信息

Nunoya T, Tajima M, Mizutani M

出版信息

Lab Anim. 1983 Apr;17(2):138-42. doi: 10.1258/002367783780959439.

Abstract

A flock of Japanese quail with generalized glycogenosis has been established. Affected quail showed difficulty in raising their wings. Excessive accumulation of glycogen was seen in the liver, heart, skeletal muscle and brain, apparently due to decreased acid maltase activity. The condition appeared between 2 and 12 weeks of age and tissue deposition of glycogen increased with age. The growth of affected quail was normal and there were no deaths from the condition. Although genetic analysis has not yet been completed, an autosomal recessive inheritance is suspected.

摘要

已经建立了一群患有全身性糖原贮积症的日本鹌鹑。患病鹌鹑表现出举翅困难。在肝脏、心脏、骨骼肌和大脑中可见糖原过度积累,这显然是由于酸性麦芽糖酶活性降低所致。这种情况出现在2至12周龄之间,糖原的组织沉积随年龄增长而增加。患病鹌鹑的生长正常,没有因这种疾病而死亡的情况。虽然基因分析尚未完成,但怀疑是常染色体隐性遗传。

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