肝片吸虫：前列腺素导致糖原磷酸化酶活性增加。

Fasciola hepatica: increase of glycogen phosphorylase activity due to prostaglandins.

作者信息

Simonic T, Sartorelli P, Locatelli A

出版信息

Exp Parasitol. 1983 Aug;56(1):89-92. doi: 10.1016/0014-4894(83)90099-1.

Abstract

Both prostaglandin E1 (PGE1) and prostaglandin F2 alpha (PGF2 alpha) stimulate the glycogen phosphorylase (EC 2.4.1.1.) activity of Fasciola hepatica. Whole or sliced parasites were incubated with PGE1 (2.8 X 10(-7) and 2.8 X 10(-5) M) and PGF2 alpha (2.1 X 10(-7) and 2.1 X 10(-5) M) and enzyme activity was measured in homogenates prepared immediately following the incubation. No substantially different effect was noted between the two assayed doses of prostaglandins. Prostaglandins appeared to be less effective in sliced parasites.

摘要

前列腺素E1（PGE1）和前列腺素F2α（PGF2α）均能刺激肝片吸虫的糖原磷酸化酶（EC 2.4.1.1.）活性。将完整或切片的寄生虫与PGE1（2.8×10⁻⁷和2.8×10⁻⁵ M）以及PGF2α（2.1×10⁻⁷和2.1×10⁻⁵ M）一起孵育，孵育后立即制备匀浆并测定酶活性。两种前列腺素的测定剂量之间未观察到明显不同的效果。前列腺素对切片寄生虫的作用似乎较小。