Seymour R A
J Clin Periodontol. 1983 May;10(3):311-6. doi: 10.1111/j.1600-051x.1983.tb01279.x.
In a double-blind, placebo-controlled study, the efficacy of 2 doses of paracetamol (500 and 1000 mg) was assessed in post-operative pain after periodontal flap surgery. Both doses of paracetamol provided greater analgesia than placebo, however, significant analgesia (P less than 0.05) was only noted in the early post-operative period. The analgesia from both doses of paracetamol did not differ significantly throughout the 3-day observation period, however, greater analgesia was attributable to 1000 mg paracetamol in the immediate post-operative period. The results from this study suggest that paracetamol is an effective analgesic for controlling post-operative pain after periodontal flap surgery, with 1000 mg dose being more effective than 500 mg immediately after surgery.
在一项双盲、安慰剂对照研究中，评估了两剂对乙酰氨基酚（500毫克和1000毫克）对牙周翻瓣术后疼痛的疗效。两剂对乙酰氨基酚均比安慰剂提供了更强的镇痛效果，然而，仅在术后早期观察到显著的镇痛作用（P小于0.05）。在为期3天的观察期内，两剂对乙酰氨基酚的镇痛效果没有显著差异，不过，术后即刻1000毫克对乙酰氨基酚的镇痛效果更强。该研究结果表明，对乙酰氨基酚是控制牙周翻瓣术后疼痛的有效镇痛药，术后即刻1000毫克剂量比500毫克更有效。
