Cade L, Ashley J
Department of Anaesthetics, Royal Women's Hospital, Carlton, Victoria, Australia.
Anaesth Intensive Care. 1993 Feb;21(1):93-6. doi: 10.1177/0310057X9302100122.
Many patients present to day surgery clinics for vaginal termination of pregnancy, a procedure which is frequently complicated by postoperative abdominal pain. We have assessed the efficacy of prophylactic paracetamol 1000 mg given orally shortly before surgery in 834 such patients in a randomised, placebo-controlled, double-blind study. Postoperative pain was reported in 35% of patients, with no significant difference between treated and control patients. This negative finding was unexpected and is so far unexplained, given the usual efficacy of oral paracetamol in relieving this type of pain after it has occurred.
许多患者前往日间手术诊所进行阴道终止妊娠手术，该手术术后常伴有腹痛并发症。我们在一项随机、安慰剂对照、双盲研究中，对834例此类患者在手术前不久口服1000毫克对乙酰氨基酚的预防效果进行了评估。35%的患者报告有术后疼痛，治疗组和对照组患者之间无显著差异。这一阴性结果出乎意料，鉴于口服对乙酰氨基酚在缓解此类疼痛方面通常的疗效，目前尚无解释。
