Knapp S, Mandell A J
Psychiatry Res. 1983 Apr;8(4):311-23. doi: 10.1016/0165-1781(83)90019-7.
Compared to control, both lithium and chlorimipramine (CMI) slow the frequency of variation in tryptophan hydroxylase (TPOH) velocity functions measured across increasing (nearly physiological) cofactor concentrations or across continuous (long residence) time. The common effect appears to be generated by different statistical mechanisms in view of the diverse patterns observed when, for multiple 60-point experiments for each condition, mean frequencies were plotted against mean amplitudes of variation: lithium constricted the frequencies over a range of amplitudes; CMI fixed amplitude across the range of frequencies. Initial rate, short residence time experiments suggest that at the micromolecular level, before the emergence of time-dependent macro-kinetic organization as seen in the long residence time assays, lithium may uncouple the elementary constituents of the system, allowing subsequent phase gathering and emergent stability around a statistically dominant frequency, whereas CMI may augment coupling, leading to unstable complexity in the population dynamics. The relationship between these effects and allosteric kinetic functions is discussed.
与对照组相比，锂盐和氯米帕明（CMI）均可减缓色氨酸羟化酶（TPOH）速度函数的变化频率，该变化频率是在增加（接近生理水平）辅因子浓度或连续（长时间停留）时间的过程中测量得到的。鉴于在每种条件下进行多次60点实验时观察到的不同模式，即当平均频率与平均变化幅度作图时，锂盐在一定幅度范围内限制频率；CMI在频率范围内固定幅度，这种共同效应似乎是由不同的统计机制产生的。初始速率、短停留时间实验表明，在分子水平上，在长时间停留实验中出现时间依赖性宏观动力学组织之前，锂盐可能会使系统的基本成分解偶联，从而允许随后围绕统计上占主导地位的频率进行相聚集和出现稳定性，而CMI可能会增强偶联，导致群体动力学中出现不稳定的复杂性。本文讨论了这些效应与变构动力学函数之间的关系。
