Lithium and chlorimipramine differentially alter bilateral asymmetry in mesostriatal serotonin metabolites and kinetic conformations of midbrain tryptophan hydroxylase with respect to tetrahydrobiopterin cofactor.
作者信息
Knapp S, Mandell A J
出版信息
Neuropharmacology. 1980 Jan;19(1):1-7. doi: 10.1016/0028-3908(80)90159-8.
PMID:7360323
Abstract
摘要
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Lithium and chlorimipramine differentially alter bilateral asymmetry in mesostriatal serotonin metabolites and kinetic conformations of midbrain tryptophan hydroxylase with respect to tetrahydrobiopterin cofactor.锂盐和氯米帕明对中脑纹状体5-羟色胺代谢产物的双侧不对称性以及与四氢生物蝶呤辅因子相关的中脑色氨酸羟化酶的动力学构象有不同影响。
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Effects of structures of tetrahydropterin cofactors on rat brain tryptophan hydroxylase.
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Lithium and chlorimipramine differentially alter the stability properties of tryptophan hydroxylase as seen in allosteric and scattering kinetics.锂和氯米帕明在变构动力学和散射动力学中对色氨酸羟化酶的稳定性特性有不同影响。
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Biopterin. VII. Inhibition of synthesis of reduced biopterins and its bearing on the function of cerebral tryptophan-5-hydroxylase in vivo.生物蝶呤。VII.还原型生物蝶呤合成的抑制及其对体内脑色氨酸-5-羟化酶功能的影响。
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A neurobiological model for the symmetrical prophylactic action of lithium in bipolar affective disorder.锂盐在双相情感障碍中对称预防性作用的神经生物学模型。
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Peripherally administered tetrahydrobiopterin increases in vivo tryptophan hydroxylase activity in the striatum after transplantation of fetal ventral mesencephalon in six hydroxydopamine lesioned rats.在6-羟基多巴胺损伤大鼠中，外周给予四氢生物蝶呤可增加胎儿腹侧中脑移植后纹状体内色氨酸羟化酶的活性。
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