Mielityinen H, Tenovuo J, Söderling E, Paunio K
Acta Odontol Scand. 1983 Jun;41(3):173-80. doi: 10.3109/00016358309162320.
Plaque formed during a 5-day xylitol or sucrose chewing gum diet was used as an irritating agent in bone and macrophage culture. The release of hydrolytic enzymes was monitored. The contents of protein, DNA, and ATP were analyzed, to characterize plaque formed during different dietary periods. The release of glycosidases and phosphatases was lower in the presence of xylitol plaque when compared with sucrose plaque as an immediate reaction in macrophage cultures at 3 h and also in bone cultures at 3 days. The results indicate that xylitol plaque had a less irritating effect on macrophages and bones in vitro than sucrose plaque according to the parameters used in this study.
在为期5天的木糖醇或蔗糖口香糖饮食期间形成的牙菌斑被用作骨和巨噬细胞培养中的刺激剂。监测水解酶的释放。分析蛋白质、DNA和ATP的含量，以表征在不同饮食阶段形成的牙菌斑。在巨噬细胞培养3小时以及骨培养3天时，与蔗糖牙菌斑相比，木糖醇牙菌斑存在时糖苷酶和磷酸酶的释放较低，这是一种即时反应。根据本研究中使用的参数，结果表明木糖醇牙菌斑在体外对巨噬细胞和骨骼的刺激作用比蔗糖牙菌斑小。
