Tenovuo J, Mielityinen H, Paunio K
Pharmacol Ther Dent. 1981;6(1-2):35-43.
Bone culture was used as an experimental model in studying the ability of dental plaque grown in the presence of xylitol or sucrose to induce bone resorption. Plaque samples were collected in young adults after six or ten days with no oral hygiene and with frequent use of xylitol- or sucrose-sweetened chewing gum. The rate of resorption was assayed by measuring the release of both acid phosphatase and 45Ca from bones into culture media during a three-day incubation period. Sucrose-induced plaque collected after ten days increased both of these indicators of bone resorption, while xylitol plaque decreased or had no effect under identical conditions. Xylitol consumption induced a marked increase in acid phosphatase activity of dental plaque - a phenomenon which would appear to be unrelated to bone resorption. The results suggest that the inflammatory potential of dental plaque may be reduced during xylitol consumption as compared to sucrose consumption.
骨培养被用作一种实验模型，用于研究在木糖醇或蔗糖存在的情况下生长的牙菌斑诱导骨吸收的能力。在没有口腔卫生措施且频繁使用木糖醇或蔗糖甜味口香糖的情况下，在年轻成年人中收集牙菌斑样本，分别在6天或10天后进行。通过在三天的培养期内测量酸性磷酸酶和45Ca从骨骼释放到培养基中的量来测定骨吸收速率。在相同条件下，10天后收集的蔗糖诱导的牙菌斑增加了这两种骨吸收指标，而木糖醇牙菌斑则降低或没有影响。食用木糖醇会导致牙菌斑酸性磷酸酶活性显著增加——这一现象似乎与骨吸收无关。结果表明，与食用蔗糖相比，食用木糖醇期间牙菌斑的炎症潜力可能会降低。
