Suhonen R, Niemi K M
Contact Dermatitis. 1978 Feb;4(1):19-28. doi: 10.1111/j.1600-0536.1978.tb03716.x.
The effect of erythemic UV irradiation on the phototoxic reactions caused by topical methoxsalen + UVA exposure was studied on normal skin, normal-looking skin of vitiligo patients, and vitiliginous skin. Although only slight histological changes were detectable 9 days after irradiation with 5 MED of erythemic UV, this pre-irradiation did induce protection against photoxic reactions in all skin types. This protection was clinically equal in all skin types; the slight differences were not statistically significant. Histological evaluation, however, showed a most conspicuous protective effect on vitiliginous skin. In all skin types the influence of UV pre-irradiation was confined to epidermal protection; the dermal phototoxic changes were unaffected.
研究了红斑紫外线照射对局部甲氧沙林+UVA暴露引起的光毒性反应的影响，研究对象包括正常皮肤、白癜风患者外观正常的皮肤以及白癜风皮肤。尽管在用5个最小红斑量（MED）的红斑紫外线照射9天后仅能检测到轻微的组织学变化，但这种预照射确实能诱导对所有皮肤类型的光毒性反应的保护作用。这种保护在所有皮肤类型中在临床上是相同的；细微差异无统计学意义。然而，组织学评估显示对白癜风皮肤有最显著的保护作用。在所有皮肤类型中，紫外线预照射的影响仅限于表皮保护；真皮光毒性变化未受影响。
