Norfolk D R, Bowen M, Roberts B E, Child J A
Br J Haematol. 1983 Oct;55(2):319-24. doi: 10.1111/j.1365-2141.1983.tb01253.x.
A significant reduction of plasma fibronectin levels was found in polycythaemia vera and myelofibrosis, the lowest levels being found in patients with marked splenomegaly. Plasma fibronectin concentration was normal in essential thrombocythaemia, and only modest reduction was seen in chronic granulocytic leukaemia in either controlled chronic phase or blast cell crisis. In a patient with myelofibrosis, the plasma fibronectin rose from less than 100 mg/l to 177 mg/l after splenectomy. Possible explanations include increased consumption of plasma fibronectin in the expanded mononuclear phagocyte system present in the liver and spleen, reduced hepatic synthesis, and the clearance of circulating immune complexes. Low plasma fibronectin concentrations may increase susceptibility to infection.
真性红细胞增多症和骨髓纤维化患者血浆纤连蛋白水平显著降低，脾肿大明显的患者血浆纤连蛋白水平最低。原发性血小板增多症患者的血浆纤连蛋白浓度正常，慢性粒细胞白血病无论是在病情得到控制的慢性期还是急变期，血浆纤连蛋白仅有适度降低。在一名骨髓纤维化患者中，脾切除术后血浆纤连蛋白从低于100mg/L升至177mg/L。可能的解释包括肝脏和脾脏中单核吞噬细胞系统扩张导致血浆纤连蛋白消耗增加、肝脏合成减少以及循环免疫复合物的清除。血浆纤连蛋白浓度低可能会增加感染易感性。
