Baglin T P, Simpson A W, Price S M, Boughton B J
Department of Haematology, Queen Elizabeth Hospital, Edgbaston, Birmingham.
J Clin Pathol. 1987 Dec;40(12):1468-71. doi: 10.1136/jcp.40.12.1468.
High concentrations of circulating immune complexes were detected by polyethylene glycol precipitation in 11 of 20 patients with myelofibrosis secondary to chronic myeloproliferative disease. Circulating immune complexes showed a positive correlation with plasma IgG concentrations both in patients and controls. Covariance analysis of the two groups showed significantly increased polyethylene glycol precipitable IgG in patients when adjusted for plasma IgG concentrations, indicating that the patients had significantly increased concentrations of complexed IgG. The immune complexes contained IgG, C3, and fibronectin and were inversely correlated with plasma fibronectin concentrations, suggesting that this major non-specific opsonin is important for the normal clearance of immune complexes. Therapeutic plasmapheresis efficiently removed circulating complexes and produced an increase in plasma fibronectin. This suggests that plasmapheresis may be useful for controlling immune complex mediated complications of these disorders.
在20例慢性骨髓增殖性疾病继发骨髓纤维化患者中，有11例通过聚乙二醇沉淀法检测到循环免疫复合物浓度较高。循环免疫复合物在患者和对照组中均与血浆IgG浓度呈正相关。两组的协方差分析显示，在调整血浆IgG浓度后，患者中聚乙二醇可沉淀IgG显著增加，表明患者中复合IgG浓度显著增加。免疫复合物含有IgG、C3和纤连蛋白，且与血浆纤连蛋白浓度呈负相关，提示这种主要的非特异性调理素对免疫复合物的正常清除很重要。治疗性血浆置换有效地清除了循环复合物，并使血浆纤连蛋白增加。这表明血浆置换可能有助于控制这些疾病中免疫复合物介导的并发症。
