一名急性髓细胞白血病患儿出现罕见的染色体易位t(2;6)和t(?;22) 。

Unusual translocations t(2;6) and t(?;22) in a child with acute myelocytic leukemia.

作者信息

Dev V G, Carroll A J, Crist W M, Peterson R D, Mankad V N

出版信息

Cancer Genet Cytogenet. 1983 Oct;10(2):205-8. doi: 10.1016/0165-4608(83)90126-7.

Abstract

A 13-month-old female with middle and upper lobe pneumonia showed a high WBC count with 99% blasts. From hematologic studies the condition was diagnosed as acute myelocytic leukemia (AML). In spite of aggressive chemotherapy, the patient died. Unstimulated peripheral blood culture and bone marrow cells revealed a translocation between a chromosome #2 and #6. An interstitial segment of 2q had been translocated to 6p. A chromosome #22 was also abnormal, having acquired a dark band around the long arm.

摘要

一名13个月大的患有中上叶肺炎的女童白细胞计数很高，原始细胞占99%。通过血液学研究，该病症被诊断为急性髓细胞白血病（AML）。尽管进行了积极的化疗，患者仍死亡。未刺激的外周血培养和骨髓细胞显示2号染色体和6号染色体之间发生了易位。2q的一个间质片段易位到了6p。22号染色体也异常，在长臂周围出现了一条暗带。