Malm L
Eur J Respir Dis Suppl. 1983;128 (Pt 1):139-42.
With two methods which in cats simultaneously recorded changes of blood flow through the mucosa of a nasal cavity and changes of the nasal patency in the same cavity, it was found that alpha-adrenoceptor agonists and the peptide, angiotensin constricted both the resistance and the capacitance vessels. Beta-adrenoceptor agonists and the peptide VIP dilated the vessels. Further, a filter paper method in dogs demonstrated that a large increase in nasal secretion was obtained with alpha-adrenoceptor stimulation in combination with methacholine, more than that with methacholine alone. Beta-adrenoceptor agonists seem to elicit a very scanty secretion. The peptide, substance P was also found to evoke a nasal secretion.
采用两种方法在猫身上同时记录鼻腔黏膜血流变化和同一鼻腔的鼻通畅度变化，发现α-肾上腺素能受体激动剂和肽类血管紧张素可使阻力血管和容量血管均收缩。β-肾上腺素能受体激动剂和肽类血管活性肠肽可使血管扩张。此外，在犬身上采用滤纸法表明，α-肾上腺素能受体刺激与乙酰甲胆碱联合应用时，鼻腔分泌物大量增加，比单独使用乙酰甲胆碱时增加得更多。β-肾上腺素能受体激动剂似乎只能引起极少的分泌物。还发现肽类物质P也可引起鼻腔分泌物增多。
