胸腺素β10，哺乳动物组织中胸腺素β4的一种新类似物。

Thymosin beta 10, a new analog of thymosin beta 4 in mammalian tissues.

作者信息

Erickson-Viitanen S, Ruggieri S, Natalini P, Horecker B L

出版信息

Arch Biochem Biophys. 1983 Sep;225(2):407-13. doi: 10.1016/0003-9861(83)90047-4.

Abstract

A new analog of thymosin beta 4 has been isolated from tissues of several mammalian species. This peptide, designated thymosin beta 10, is composed of 42 amino acid residues and shows 75% sequence homology with thymosin beta 4. It occurs together with thymoxin beta 4 in a variety of tissues including spleen, liver, and thymus and also in several cultured cell lines. In the spleen of rat, mouse, cat, and man, the new peptide accounts for approximately 0.02% by weight of the total protein. In the calf it is replaced by another homologous peptide, designated thymosin beta 9, whose structure has been reported.

摘要

一种新的胸腺素β4类似物已从几种哺乳动物的组织中分离出来。这种肽被命名为胸腺素β10，由42个氨基酸残基组成，与胸腺素β4的序列同源性为75%。它与胸腺素β4一起存在于多种组织中，包括脾脏、肝脏和胸腺，也存在于几种培养的细胞系中。在大鼠、小鼠、猫和人的脾脏中，这种新肽约占总蛋白重量的0.02%。在小牛中，它被另一种同源肽胸腺素β9所取代，其结构已被报道。