Keshgegian A A, Enterline H T
Dis Colon Rectum. 1978 May-Jun;21(4):255-60. doi: 10.1007/BF02586699.
A case of a woman with Gardner's syndrome, originally manifested by multiple adenomatous polyps of the colon, is presented. She underwent subtotal colectomy at 14 years of age. Over the next 15 years she had a composite odontoma, an impacted supernumerary tooth, two epidermal inclusion cysts, multicentric paillary-follicular adenocarcinoma of the thyroid, two tubulovillous adenomas of the duodenum in which argyrophilic cells were a prominent feature, and an adenomyoma of the gastric antrum. The presence of all of these lesions in one patient expands the spectrum of lesions seen with Gardner's syndrome and supports the concept of a generalized abnormality of growth regulation as the cause of the syndrome.
本文报告一例加德纳综合征患者，最初表现为结肠多发腺瘤性息肉。她14岁时接受了结肠次全切除术。在接下来的15年里，她出现了复合性牙瘤、一颗阻生多生牙、两个表皮样囊肿、甲状腺多中心乳头状滤泡腺癌、十二指肠两个以嗜银细胞为显著特征的管状绒毛状腺瘤以及胃窦部腺肌瘤。同一患者出现所有这些病变，扩展了加德纳综合征所见病变的范围，并支持生长调节普遍异常是该综合征病因的概念。
