Hahn R, Oette K, Mondorf H, Finke K, Sieberth H G
Atherosclerosis. 1983 Sep;48(3):279-88. doi: 10.1016/0021-9150(83)90045-x.
A group of 252 chronic hemodialysis patients was examined for various risk factors. Special emphasis was placed upon the comparison of patients who had marked cardiovascular alterations with the remainder of the group. The seriousness of the risk factors was determine by hypertension and hyperlipoproteinemia, 78% of the patients received antihypertensive medication or had changes in the fundus of the eye or both. In 74% of the patients there were pathological changes in the plasma lipids or lipoproteins or both. Hypertriglyceridemia (49%) and a HDL cholesterol decrease (61%) were the most striking findings. The average VLDL cholesterol value was significantly higher and the HDL cholesterol significantly lower in the coronary heart disease group than in the remaining group. These results show that hyperlipoproteinemia and a decrease in HDL, together with other risk factors such as hypertension and anemia, play an important role in the accelerated development of atherosclerosis in a hemodialysis group.
对一组252名慢性血液透析患者进行了各种危险因素检查。特别着重比较了有明显心血管改变的患者与该组其他患者。危险因素的严重程度由高血压和高脂蛋白血症决定，78%的患者接受了抗高血压药物治疗，或眼底有改变，或两者皆有。74%的患者血浆脂质或脂蛋白或两者有病理改变。高甘油三酯血症（49%）和高密度脂蛋白胆固醇降低（61%）是最显著的发现。冠心病组的平均极低密度脂蛋白胆固醇值显著高于其余组，而高密度脂蛋白胆固醇则显著低于其余组。这些结果表明，高脂蛋白血症和高密度脂蛋白降低，连同高血压和贫血等其他危险因素，在血液透析组动脉粥样硬化的加速发展中起重要作用。
