Waldinger T P, Ellis C N, Quint K, Voorhees J J
Arch Dermatol. 1983 Dec;119(12):1003-5.
A patient with chronic cutaneous and pulmonary sarcoidosis, unresponsive to oral corticosteroid therapy, was treated with isotretinoin. The patient's cutaneous manifestations of sarcoidosis showed consistent improvement during the course of retinoid therapy. The lesions that responded earliest either resolved or showed the greatest reduction in size. The patient's WBC count increased and her angiotensin-converting enzyme level decreased during the first two months of isotretinoin therapy; both returned to pretreatment levels during the third month of therapy. Pulmonary function tests were unchanged after four months of treatment. Isotretinoin may be a useful therapeutic agent for cutaneous sarcoidosis. However, the possibility of spontaneous remission of the disease during the course of therapy cannot be excluded.
一名患有慢性皮肤和肺部结节病的患者，对口服皮质类固醇治疗无反应，接受了异维A酸治疗。在维甲酸治疗过程中，该患者结节病的皮肤表现持续改善。最早出现反应的病变要么消退，要么尺寸缩小最为明显。在异维A酸治疗的前两个月，患者的白细胞计数升高，血管紧张素转换酶水平下降；在治疗的第三个月，两者均恢复到治疗前水平。治疗四个月后，肺功能测试无变化。异维A酸可能是治疗皮肤结节病的一种有用药物。然而，不能排除在治疗过程中疾病自发缓解的可能性。
