Svendsen T L, Hartling O, Trap-Jensen J
Eur J Clin Pharmacol. 1978 May 17;13(2):91-5. doi: 10.1007/BF00609751.
The effect of adrenergic beta receptor blockade on the elimination rate of ethanol was studied in seven healthy young men. The studies were performed before and after 14 days of propranolol 240 mg/day: the ethanol was given per-orally--0.8 mg/kg b.w. The blood concentration of ethanol, glucose, lactate and glycerol, and the plasma concentration of free fatty acids and triglycerides were followed in samples from the superior vena cava taken every 20 min for four hours. The splanchnic hepatic blood flow was estimated with a single i.v. injection of indocyanine green. The absorption rate, absorption fraction and elimination rate of ethanol were not changed by propranolol. The splanchnic hepatic blood flow was significantly reduced (mean 19 per cent) during beta receptor blockade. The ethanol-induced change in the concentration of glucose, lactate and free fatty acids was affected by propranolol, the time-concentration curves for glucose and lactate being significantly elevated and that for free fatty acids being significantly reduced. The time-concentration curves for glycerol and triglycerides did not differ in the two studies.
在7名健康年轻男性中研究了肾上腺素能β受体阻滞剂对乙醇消除率的影响。研究在每天服用240 mg普萘洛尔14天前后进行：口服给予乙醇——0.8 mg/kg体重。在4小时内，每隔20分钟从颈静脉采集样本，监测乙醇、葡萄糖、乳酸和甘油的血药浓度，以及游离脂肪酸和甘油三酯的血浆浓度。通过单次静脉注射吲哚菁绿估计内脏肝血流量。普萘洛尔未改变乙醇的吸收速率、吸收分数和消除率。在β受体阻滞剂作用期间，内脏肝血流量显著降低（平均降低19%）。普萘洛尔影响了乙醇诱导的葡萄糖、乳酸和游离脂肪酸浓度变化，葡萄糖和乳酸的时间-浓度曲线显著升高，游离脂肪酸的时间-浓度曲线显著降低。甘油和甘油三酯的时间-浓度曲线在两项研究中无差异。
