Koprowski H, Herlyn D, Lubeck M, DeFreitas E, Sears H F
Proc Natl Acad Sci U S A. 1984 Jan;81(1):216-9. doi: 10.1073/pnas.81.1.216.
Inoculation of human subjects with mouse monoclonal antibody results in the production of anti-idiotype antibody that reacts with the binding site of the monoclonal antibody. This reaction is hapten-inhibited, suggesting that an internal image of the antigen is produced by the anti-idiotype response. The anti-idiotype antibody isolated from sera of three patients showed significant crossreactivity. Patients who developed the anti-idiotype antibody improved clinically and had long remission from their disease. The possible presence of the internal image of cancer antigen on the human immunoglobulin molecule may change the conditions under which the immune system reacts to the tumor antigen and may open new approaches to the control of tumor growth.
用小鼠单克隆抗体接种人体受试者会导致产生抗独特型抗体，该抗体与单克隆抗体的结合位点发生反应。这种反应受半抗原抑制，提示抗独特型反应产生了抗原的内影像。从三名患者血清中分离出的抗独特型抗体显示出显著的交叉反应性。产生抗独特型抗体的患者临床症状改善，疾病长期缓解。人免疫球蛋白分子上可能存在的癌抗原内影像可能会改变免疫系统对肿瘤抗原作出反应的条件，并可能为控制肿瘤生长开辟新途径。
