Mitchell D E, Murphy K M, Kaye M G
Proc Natl Acad Sci U S A. 1984 Jan;81(1):286-8. doi: 10.1073/pnas.81.1.286.
Kittens were monocularly deprived by closing one eye at the time of natural eye opening for periods that ranged from 4 to 14 weeks. This eye was then opened, and the other eye was closed for an approximately equal period of time. During this period of reverse occlusion, the vision of the initially deprived eye improved from apparent blindness to a level of good visual acuity. Surprisingly, however, this recovery was largely eliminated in only 2 weeks once the initially nondeprived eye was opened to restore visual input to both eyes. This finding has important implications for the nature of the mechanism(s) responsible for the dramatic physiological effects of monocular occlusion on the visual cortex. It may also help to elucidate recent observations on patching therapy in human amblyopia.
小猫在自然睁眼时单眼被剥夺视觉，剥夺时间为4至14周。然后睁开这只眼，另一只眼关闭大约相同的时间。在这段反向遮盖期间，最初被剥夺视觉的眼睛的视力从明显失明提高到良好的敏锐度水平。然而，令人惊讶的是，一旦最初未被剥夺视觉的眼睛睁开以恢复双眼的视觉输入，这种恢复在仅2周内就基本消失了。这一发现对于单眼遮盖对视觉皮层产生显著生理效应的机制的本质具有重要意义。它也可能有助于阐明最近关于人类弱视遮盖疗法的观察结果。
