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复杂视幻觉与环孢素

Complex visual hallucinations and cyclosporine.

作者信息

Noll R B, Kulkarni R

出版信息

Arch Neurol. 1984 Mar;41(3):329-30. doi: 10.1001/archneur.1984.04050150111026.

DOI:10.1001/archneur.1984.04050150111026
PMID:6582812
Abstract

Insidious loss of visual acuity and simultaneous onset of complex visual hallucinations were observed in a patient with acute lymphoblastic leukemia who had recently received bone marrow transplantation and was being treated with prednisone and cyclosporine to suppress graft-v-host disease. Problems with visual acuity and visual hallucinations spontaneously ameliorated with reduction and termination of cyclosporine treatment. The complex visual hallucinations caused considerable psychological distress for the patient. These hallucinatory phenomena were placed within the framework of loss of control and decreased competence, often experienced by children with chronic illness. Recommendations for prompt therapeutic intervention were made.

摘要

在一名急性淋巴细胞白血病患者中观察到视力逐渐丧失并同时出现复杂的视幻觉,该患者最近接受了骨髓移植,正在接受泼尼松和环孢素治疗以抑制移植物抗宿主病。随着环孢素治疗的减少和终止,视力问题和视幻觉自发改善。复杂的视幻觉给患者带来了相当大的心理困扰。这些幻觉现象被置于慢性病患儿常经历的控制丧失和能力下降的框架内。提出了及时进行治疗干预的建议。

相似文献

1
Complex visual hallucinations and cyclosporine.复杂视幻觉与环孢素
Arch Neurol. 1984 Mar;41(3):329-30. doi: 10.1001/archneur.1984.04050150111026.
2
Methotrexate and cyclosporine compared with cyclosporine alone for prophylaxis of acute graft versus host disease after marrow transplantation for leukemia.甲氨蝶呤与环孢素联合应用与单独使用环孢素预防白血病骨髓移植后急性移植物抗宿主病的比较。
N Engl J Med. 1986 Mar 20;314(12):729-35. doi: 10.1056/NEJM198603203141201.
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[Toxic retinopathy in cyclosporin A therapy].[环孢素 A 治疗中的中毒性视网膜病变]
Klin Monbl Augenheilkd. 1987 Feb;190(2):131-4. doi: 10.1055/s-2008-1050344.
4
Visual hallucinations and cyclosporine.视幻觉与环孢素
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5
A prospective randomized study of acute graft-v-host disease in 107 patients with leukemia: methotrexate/prednisone v cyclosporine A/prednisone.107例白血病患者急性移植物抗宿主病的前瞻性随机研究:甲氨蝶呤/泼尼松与环孢素A/泼尼松对比
Transplant Proc. 1987 Feb;19(1 Pt 3):2605-7.
6
Cyclosporine neurotoxicity in heart transplantation.
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7
Complex visual hallucinations and cyclosporine neurotoxicity.复杂视幻觉与环孢素神经毒性
Neurology. 1991 Jul;41(7):1156. doi: 10.1212/wnl.41.7.1156.
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9
Treatment of acute graft-versus-host disease after allogeneic marrow transplantation. Randomized study comparing corticosteroids and cyclosporine.
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Cotton-wool exudates not observed in recipients of renal transplants treated with cyclosporine.接受环孢素治疗的肾移植受者未观察到棉絮状渗出物。
Transplantation. 1986 Jan;41(1):60-2. doi: 10.1097/00007890-198601000-00012.

引用本文的文献

1
Variable incidence of cyclosporine and FK-506 neurotoxicity in hematopoeitic malignancies and marrow conditions after allogeneic bone marrow transplantation.异基因骨髓移植后,造血系统恶性肿瘤和骨髓疾病中环孢素和FK - 506神经毒性的发生率各异。
Neurocrit Care. 2005;3(1):33-45. doi: 10.1385/NCC:3:1:033.
2
Pretransplantation conditioning influence on the occurrence of cyclosporine or FK-506 neurotoxicity in allogeneic bone marrow transplantation.移植前预处理对异基因骨髓移植中环孢素或FK-506神经毒性发生的影响。
AJNR Am J Neuroradiol. 2004 Feb;25(2):261-9.
3
Etiology of cortical and white matter lesions in cyclosporin-A and FK-506 neurotoxicity.
环孢素A和FK-506神经毒性中皮质和白质病变的病因学。
AJNR Am J Neuroradiol. 2001 Nov-Dec;22(10):1901-14.
4
Progressive visual deterioration leading to blindness after pediatric heart transplantation.小儿心脏移植术后渐进性视力减退导致失明。
Tex Heart Inst J. 1993;20(4):299-303.
5
Cyclosporin A toxicity: MRI appearance of the brain.环孢素A毒性:脑的磁共振成像表现
Pediatr Radiol. 1995;25(3):180-3. doi: 10.1007/BF02021528.
6
Adverse reactions and interactions of cyclosporin.环孢素的不良反应及相互作用。
Med Toxicol Adverse Drug Exp. 1988 Mar-Apr;3(2):107-27. doi: 10.1007/BF03259936.
7
The pathophysiology of Sandimmune (cyclosporine) in man and animals.山地明(环孢素)在人和动物体内的病理生理学
Pediatr Nephrol. 1990 Nov;4(6):686-704. doi: 10.1007/BF00858649.