Rondot P, Ziegler M
J Neural Transm Suppl. 1983;19:273-81.
Four cases of dystonia occurring in two families are reported. The first symptoms consisting of dystonia and rigidity appeared early in childhood, in the first months in one family and of ages two and five years respectively in the other. In two cases, transient tremor was noted. These four children have been treated with L-dopa with prompt spectacular results, in cases 1 and 2, with more gradual less complete results in the others. L-dopa treatment was continued twelve, eleven, six, and five years, respectively, without any developmental problems. Motor function remains satisfactory and school work is normal. The only secondary effect observed was the occurrence of dyskinesia. The relation between L-dopa responsive dystonia and Parkinson's disease is discussed.
本文报告了两个家族中出现的4例肌张力障碍病例。最初症状为肌张力障碍和僵硬，均在儿童早期出现，其中一个家族在最初几个月出现，另一个家族分别在2岁和5岁时出现。2例出现短暂性震颤。这4名儿童均接受了左旋多巴治疗，病例1和病例2迅速取得显著疗效，其他病例疗效较缓慢且不完全。左旋多巴治疗分别持续了12年、11年、6年和5年，未出现任何发育问题。运动功能保持良好，学业正常。观察到的唯一副作用是出现运动障碍。文中讨论了左旋多巴反应性肌张力障碍与帕金森病之间的关系。
