Zolotnikova G P, Dorofeev V M
Farmakol Toksikol. 1978 Mar-Apr;41(2):186-8.
Tests on a culture of embryonal fibroblast cells furnished preliminary data on a possible use of vitamins C, PP, folic acid and methionine in preventing the toxic effects of phosphamide and acrex. An appreciable lowering of the degeneration factor in cultivated cells produced by the cytotoxic action of phosphamide was noted in the presence of vitamin C, methionine, folic acid, choline hydrochloride and vitamin PP and of that exerted by acrex-by adding into the incubation medium of vitamins B1, B2, C, PP, folic acid or methionine. It is advisable that these substances be subjected to a continued investigation in animals with a view of elaborating practical recommendations for their utilization in preventing toxic effects of pesticides on the human organism.
对胚胎成纤维细胞培养物进行的试验提供了关于维生素C、PP、叶酸和蛋氨酸在预防磷酰胺和阿克里克斯毒性作用方面可能用途的初步数据。在维生素C、蛋氨酸、叶酸、盐酸胆碱和维生素PP存在的情况下，以及在阿克里克斯作用下，通过向培养介质中添加维生素B1、B2、C、PP、叶酸或蛋氨酸，发现磷酰胺细胞毒性作用所产生的培养细胞退化因子明显降低。建议对这些物质在动物身上进行持续研究，以便为其在预防农药对人体毒性作用方面的应用制定实际建议。
