Samoĭlova Z T, Kliukina S S, Khaliutina L V, Shchitkov K G
Farmakol Toksikol. 1978 Mar-Apr;41(2):218-22.
In tests conducted with 165 mongrel sexually mature and immature rats it is shown that azathioprine used in nephrotoxic nephritic improves the general condition, reduces the edema of subcutaneous cellular tissues, as well as the intensity of proteinuria and helps retaining its selective type, lessens the degree of hypo- and dpsproteinemia and, especially, of hyper-beta-lipoproteinemia; in the kidneys the pathomorphological changes characteristic of nephritis become less marked. Azathioprine does not influence the process of acido-and ammoniogeness in the tubuloar system of the nephron, nor does it modify diuresis. The effect of azathioprine is most spectacular in the acive phase of developing nephritis. In rattlings with nephritis theaction af azathioprine in regard to a number of factors (proteins, beta-lipoproteids, gamma-globulins of the blood) is somewhat stronger than in the sexually mature rats.
在用165只性成熟和未成熟的杂种大鼠进行的试验中表明，用于肾毒性肾炎的硫唑嘌呤可改善一般状况，减轻皮下细胞组织水肿以及蛋白尿的强度，并有助于保持其选择性类型，减轻低蛋白血症和高β-脂蛋白血症的程度，尤其是高β-脂蛋白血症；在肾脏中，肾炎特有的病理形态学变化变得不那么明显。硫唑嘌呤不影响肾单位肾小管系统中的酸生成和氨生成过程，也不改变利尿作用。硫唑嘌呤的作用在肾炎发展的急性期最为显著。在患肾炎的大鼠中，硫唑嘌呤对一些因素（血液中的蛋白质、β-脂蛋白、γ-球蛋白）的作用比对性成熟大鼠的作用稍强。
