Hsu C, Choo Y C, Seto W H, Pang S W, Tan C Y, Merigan T C, Ng M H
Acta Cytol. 1984 Mar-Apr;28(2):111-7.
Local interferon injection in four patients with cervical intraepithelial neoplasia (CIN) regularly elicited progressive regression of the lesions. The response was observed with exfoliative cytology after each injection, guided by colposcopic examination. The cytologic changes showed a cytocidal effect mainly on the dyskaryotic cells, preceded by cellular degeneration not unlike that of nonspecific inflammation and accompanied by an increase in neutrophil infiltration. The cytologic response was closely correlated with partial or complete clinical regression based on the absence of viable or degenerated dyskaryotic cells in the cervical smears. Three patients showed complete clinical regression after treatment. One patient showed recurrent viable dyskaryotic cells when the dosage was reduced, and treatment was suspended temporarily although her lesion had regressed completely after five injections. Clinical recurrence was noted one week after viable dyskaryotic cells reappeared in her smears. These observations suggest that cytology may be a useful means of monitoring interferon treatment in CIN.
对四名宫颈上皮内瘤变（CIN）患者进行局部干扰素注射，定期引发病变的逐步消退。每次注射后，在阴道镜检查的引导下，通过脱落细胞学观察反应。细胞学变化显示主要对核异质细胞有细胞杀伤作用，之前有类似于非特异性炎症的细胞变性，并伴有中性粒细胞浸润增加。基于宫颈涂片无存活或变性核异质细胞，细胞学反应与部分或完全临床消退密切相关。三名患者治疗后临床完全消退。一名患者在减少剂量时出现复发生存的核异质细胞，尽管她在五次注射后病变已完全消退，但治疗仍暂时中止。在她的涂片再次出现存活的核异质细胞一周后，出现了临床复发。这些观察结果表明，细胞学可能是监测CIN患者干扰素治疗的有用手段。
