Waerhaug M, Gjermo P, Rølla G, Johansen J R
J Clin Periodontol. 1984 Mar;11(3):176-80. doi: 10.1111/j.1600-051x.1984.tb01321.x.
Recent studies have shown that several metal ions inhibit plaque formation and reduce the acidogenicity of dental plaque. The aim of the present study was to compare the effect on plaque and gingivitis of 2.2 mM CuSO4 with an equimolar solution of chlorhexidine in a modified experimental gingivitis model. The study was performed according to a double-blind cross-over design. Before each experimental period the GI was recorded and the participants' teeth were scaled and polished to remove all supragingival deposits. All mechanical oral hygiene was suspended during the experimental periods. The mean PII after rinsing with chlorhexidine, CuSO4 and water was 0.29, 0.79 and 1.25, respectively. The corresponding GI values were 0.57, 0.83 and 1.02. All differences were statistically significant. The results showed that CuSO4 inhibits plaque formation and development of gingivitis, but not to the same degree as chlorhexidine.
最近的研究表明，几种金属离子可抑制牙菌斑形成并降低牙菌斑的产酸性。本研究的目的是在改良的实验性牙龈炎模型中，比较2.2 mM硫酸铜与等摩尔洗必泰溶液对牙菌斑和牙龈炎的影响。该研究按照双盲交叉设计进行。在每个实验期之前记录牙龈指数（GI），并对参与者的牙齿进行洁治和抛光以清除所有龈上沉积物。在实验期内暂停所有机械口腔卫生措施。用洗必泰、硫酸铜和水冲洗后的平均菌斑指数（PII）分别为0.29、0.79和1.25。相应的牙龈指数值分别为0.57、0.83和1.02。所有差异均具有统计学意义。结果表明，硫酸铜可抑制牙菌斑形成和牙龈炎的发展，但程度不如洗必泰。
